EPISODE · Feb 26, 2026 · 20 MIN
557-CD8+ T细胞分化转录因子图谱与免疫治疗精准编程
from 聊聊Sci
这项研究通过建立CD8+ T细胞的转录与表观遗传图谱，揭示了调控细胞状态转换的核心转录因子（TF）机制。研究利用Taiji管线识别出驱动组织驻留记忆（TRM）与终末耗竭（TEXterm）等不同状态的关键因子，并发现蛋白酶体通路是细胞功能障碍的重要标志。通过在小鼠体内进行的Perturb-seq筛选，作者证实了Zscan20和Jdp2等新型转录因子在控制T细胞耗竭中的关键作用。实验表明，敲除这些特定因子不仅能抑制细胞耗竭，还能与免疫检查点阻断（ICB）疗法协同作用，显著增强抗肿瘤效果。该成果为通过细胞状态工程优化过继性细胞疗法提供了精准的基因调控方案。这一研究框架同样具有扩展至其他细胞类型和疾病治疗领域的潜力。References: Chung H K, Liu C, Battu A, et al. Atlas-guided discovery of transcription factors for T cell programming[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动
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557-CD8+ T细胞分化转录因子图谱与免疫治疗精准编程
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