EPISODE · Feb 26, 2026 · 17 MIN
559-肿瘤-大脑轴调控癌症免疫机制研究
from 聊聊Sci
这项研究揭示了大脑与外周肿瘤之间存在一种复杂的双向通讯机制，特别是在肺癌的发展过程中。研究发现，实性肿瘤能够通过外周神经系统与中枢神经建立联系，形成一个由感觉神经和交感神经组成的调控轴。当肺部出现肿瘤时，这种神经回路会被激活，进而抑制机体的癌症免疫反应，从而促进恶性病变的表型和不良预后。实验证明，通过化学遗传学方法或药物干预来阻断这一神经信号传导，可以有效增强免疫监视并减缓肿瘤生长。此外，临床数据也印证了高水平的肿瘤神经支配与肺腺癌患者较低的存活率及受损的CD8 T细胞功能密切相关。该成果为开发针对神经系统的抗癌新疗法提供了重要的理论依据。References: Wei H K, Yu C D, Hu B, et al. Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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559-肿瘤-大脑轴调控癌症免疫机制研究
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