56 - La Grippe

The 1889 Russian Flu was the first influenza pandemic in an increasingly globalized world. In this episode, the second of a two-parter on how hydroxychloroquine became a great hope in COVID-19, we'll talk about how quinine became the standard of care for influenza. Along the way, we'll discuss the astrological origins of the flu, the nosological difficulties of identifying past pandemics, conspiracy theories about previous global coronavirus outbreaks, the media panic over the Russian Flu, first year law school cases about Carbolic Smoke Balls, and the first studies into quinine's efficacy in influenza.    References   Seeler, A. O., Graessle, O. & Ott, W. H. Effect of Quinine on Influenza Virus Infections in Mice. J Infect Dis 79, 156–158 (1946). Barberis, I., Myles, P., Ault, S. K., Bragazzi, N. L. & Martini, M. History and evolution of influenza control through vaccination: from the first monovalent vaccine to universal vaccines. J Prev Medicine Hyg 57, E115–E120 (2016). Ewing, E. T. La Grippe or Russian influenza: Mortality statistics during the 1890 Epidemic in Indiana. Influenza Other Resp 13, 279–287 (2019). Gold, E. Pandemic Influenza 1700-1900: A Study in Historical Epidemiology. Jama 257, 2656–2656 (1987). Rice, G. W. & Palmer, E. Pandemic Influenza in Japan, 1918-19: Mortality Patterns and Official Responses. J Jpn Stud 19, 389 (1993). Mulder, J., Masurel, N., Deggars, E. M. & Webbers, P. T. PRE-EPIDEMIC ANTIBODY AGAINST 1957 STRAIN OF ASIATIC INFLUENZA IN SERUM OF OLDER PEOPLE LIVING IN THE NETHERLANDS. Lancet 271, 810–814 (1958). Refresher Course for General Practitioners. J Amer Med Assoc 152, 773 (1953). Moore, J. W. The influenza epidemic of 1889–90, as observed in Dublin. Transactions Royal Acad Medicine Irel 8, 56–74 (1890). Textbook of Influenza. (n.d.). Coghill, J. G. S. The Prophylaxis of Influenza. Brit Med J 1, 751 (1895). When early modern Europe caught the flu. A scientific account of pandemic influenza in sixteenth century Sicily. (n.d.). Potter. A history of influenza.  Valleron AJ et al, Transmissibility and geographic spread of the 1889 influenza pandemic. PNAS May 11, 2010 107 (19) 8778-8781 Cavallaro JJ and Monto AS. Community-wide Outbreak of Infection with a 229E-like Coronavirus in Tecumseh, Michigan.The Journal of Infectious Diseases. Vol. 122, No. 4 (Oct., 1970), pp. 272-279 Mulder J and Masurel N, Pre-epidemic Antibody Against 1957 Strain of Asiatic Influenza in Serum of Older People Living in the Netherlands. Lancet. 1958 Apr 19;1(7025):810-4 Vijgen L et al. Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event. J Virol. 2005 Feb; 79(3): 1595–1604. Saunders-Hastings PR and Krewski D. Reviewing the History of Pandemic Influenza: Understanding Patterns of Emergence and Transmission. Pathogens. 2016 Dec; 5(4): 66. Pappas G et al. Insights into infectious disease in the era of Hippocrates.International Journal of Infectious Diseases Volume 12, Issue 4, July 2008, Pages 347-350. Flint A, Principles and Practice of Medicine. https://collections.nlm.nih.gov/bookviewer?PID=nlm:nlmuid-100894695-bk#page/234/mode/2up/search/influenza Osler W, Principles and Practice of Medicine.  https://archive.org/details/principlespract00osle/page/1002/mode/2up Taubenberger JK and Morens DM. Influenza: The Once and Future Pandemic. Public Health Rep. 2010; 125(Suppl 3): 16–26. Shope RE. Influenza: history, epidemiology, and speculation. Public Health Rep. 1958 Feb; 73(2): 165–179. Ewing ET. Will It Come Here? Using Digital Humanities Tools to Explore Medical Understanding during the Russian Flu Epidemic, 1889–90. Med Hist. 2017 Jul; 61(3): 474–477.