#56 - Muscle plasticity, aging and exercise with Dr Benjamin Miller

Dr Glenn McConell chats with Professor Benjamin Miller from the Oklahoma Medical Research Foundation (OMRF) who is an expert on muscle proteostasis /plasticity in response to exercise and aging. He has evidence that muscle atrophy with aging may be due more to increased protein breakdown than reduced protein synthesis. He also has found that the top diabetes drug metformin can impair some of the benefits of exercise.0:00. Introduction and Benjamin’s current employment etc6:09. Benjamin’s early background in exercise and science8:05. Healthspan vs lifespan. Can extend lifespan?13:12. Metformin can impair some of the benefits of exercise20:15. Metformin and healthspan/lifespan23:05. Prescribing metformin to diabetics before diet/exercise25:20. Drugs aren’t as good as exercise for healthspan27:20. Proteostasis (protein homeostasis)29:20. Muscle atrophy with aging: mainly due to protein breakdown?36:40. Muscle fibers have many nuclei39:00. Muscle nucleus DNA duplication 42:30. Satellite cells not so important for myonuclei?45:45. Benjamin’s tracer study methods using D2O49:50. Myonuclear domain, weight training, muscle memory52:02. Mechanisms of acute atrophy vs aging54:25. Mitochondria interactions with proteostasis57:30. Aging drugs and interactions with exercise59:40. Statins, exercise and muscle1:00:20. Exercise better than drugs for healthspan1:00:40. Lactate infusions during exercise1:04:20. Lactate, exercise and cognitive function.1:05:20. Tendon collagen synthesis and turnover (and exercise)1:13:15. Muscle nuclei can migrate to damaged area1:13:57. Takeaway messages1:16:58. Outro (9 seconds)Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice