EPISODE · Feb 27, 2026 · 15 MIN
562-脑血管阻断通过硬膜巨噬细胞增强胶质瘤免疫
from 聊聊Sci
这项研究揭示了硬脑膜在对抗胶质母细胞瘤（GBM）等中枢神经系统肿瘤中的关键免疫调节作用。研究人员开发了一种名为硬脑膜血管阻断（MBB）的手术策略，通过结扎颈外动脉选择性减少硬脑膜血供，而不损伤脑实质。这种干预改变了脑膜巨噬细胞（BAM）的组成，使具有强大抗原呈递能力的rBAM群体扩张，从而激活针对肿瘤的T细胞免疫反应。实验证明，MBB能显著抑制小鼠体内的肿瘤生长，并与PD-1抑制剂具有协同治疗效果。此外，人类临床数据证实，硬脑膜中rBAM的比例与患者的生存期呈正相关。这一发现打破了大脑免疫特权的传统认知，提出硬脑膜是增强神经系统癌症免疫治疗的潜在靶点。References: Gao Y, Peng Y, Cheng J, et al. Meningeal blood vessel blockage enhances anti-glioblastoma immunity[J]. Cell, 2026.前往小宇宙评论区与主播互动
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562-脑血管阻断通过硬膜巨噬细胞增强胶质瘤免疫
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