EPISODE · Mar 2, 2026 · 20 MIN
572-肿瘤-免疫-神经环路驱动癌症恶病质机制研究
from 聊聊Sci
这项研究揭示了一个由肿瘤细胞、免疫细胞（巨噬细胞）和神经系统构成的三方循环机制，该机制共同驱动了癌症恶病质和厌食症。研究发现，肿瘤分泌的CSF1会诱导巨噬细胞产生GDF15，这种细胞因子随后激活大脑中的GFRAL-RET通路并增强交感神经活性。神经末梢释放的去甲肾上腺素会反过来上调肿瘤中的ZIP4和CSF1，形成一种自我放大的病理反馈环路。这种恶性循环导致了严重的肌肉萎缩、脂肪流失和能量代谢失衡。实验证明，通过药物阻断该轴线上的任一环节，均能有效缓解癌症模型中的衰竭症状，为治疗癌症恶病质提供了新的治疗策略。References: Shi X, Arreola A X, Zhou Z, et al. Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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572-肿瘤-免疫-神经环路驱动癌症恶病质机制研究
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