595-全脑单细胞分辨率分子细胞图谱

这项研究介绍了 BrainCAD 平台，这是一项结合转基因荧光标记与 fMOST 高分辨率成像技术的新型神经科学工具。通过对 20 种分子定义的神经元和胶质细胞进行全脑制图，研究者构建了一个精确到 10 微米分辨率的三维细胞图谱。该研究不仅量化了不同脑区的细胞数量与密度，还通过无监督聚类分析发现了传统解剖边界之外的精细功能分区。此外，该平台揭示了兴奋性与抑制性神经元在全脑空间分布上的比例差异及规律。这一成果为理解哺乳动物大脑的结构异质性提供了标准化的高质量数据资源，并可通过 MiCAM 网络门户进行交互访问。References:* Zhao M, Zhou J, Jiang T, et al. Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resoluti...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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595-全脑单细胞分辨率分子细胞图谱

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