6 2 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis

 Journal of  American Medical Association

 Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

The KARDIA-2 Randomized Clinical Trial

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

The A2B Randomized Clinical Trial

 Annals of Internal Medicine

Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States

  British Medical Journal

A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China

  Lancet

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial

 journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

 Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

 Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

 Rheumatology 

Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease

 Journal of Clinical Rheumatology 

Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis

 Circulation

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension

   Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

  JAMA Cardiology

Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration

  Journal of Clinical Endocrinology & Metabolism

Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study

 Neurology

Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years

 Chest

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest

 The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

 Clinical Journal of American Society of Nephrology

High-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD

 Kidney International reports

Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease