6 2 2025

Hi, This Week in Medicine, we will be discussing New England Journal of MedicineSotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis Journal of  American Medical Association Add-On Treatment With Zilebesiran for Inadequately Controlled HypertensionThe KARDIA-2 Randomized Clinical Trial Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill PatientsThe A2B Randomized Clinical Trial  Annals of Internal MedicineTrends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States  British Medical JournalA village doctor-led mobile health intervention for cardiovascular risk reduction in rural China  LancetNegative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial journal of HepatologyUtility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH Gastroenterology Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease Clinical Gastroenterology The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation Rheumatology Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease Journal of Clinical Rheumatology Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis CirculationExploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension   Journals of the American College of CardiologyDisentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction  JAMA CardiologyClinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration  Journal of Clinical Endocrinology & MetabolismFetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study  NeurologyStability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years ChestVideo vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest  The American Journal of Respiratory and Critical Care MedicineImpact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial Clinical Journal of American Society of NephrologyHigh-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD Kidney International reportsKidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease