6 9 2025

Hi, This Week in Medicine, we will be discussing New England Journal of MedicinePhase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes  Journal of  American Medical AssociationClinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer Annals of Internal MedicineEffects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery  LancetComparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial  Journal of Clinical OncologyExplaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study  journal of HepatologyUtility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH   Gastroenterology Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease  Clinical Gastroenterology The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation Clinical Infectious DiseasesAssociation Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes Rheumatology Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases  Journals of the American College of CardiologyDisentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction  JAMA CardiologySex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis  Diabetes careCardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials   NeurologyAssociation of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study  ChestClinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis The American Journal of Respiratory and Critical Care MedicineImpact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial  Clinical Journal of American Society of NephrologyClinical Implications of Slope of GFR in Clinical Trials of CKD Progression Kidney International reportsNephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists