6 9 2025

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules

Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy

A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes

  Journal of  American Medical Association

Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer

 Annals of Internal Medicine

Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery

  Lancet

Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial

  Journal of Clinical Oncology

Explaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study

  journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

   Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

  Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

 Clinical Infectious Diseases

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes

 Rheumatology 

Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases

  Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

  JAMA Cardiology

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis

  Diabetes care

Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials 

  Neurology

Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

  Chest

Clinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis

 The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

  Clinical Journal of American Society of Nephrology

Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression

 Kidney International reports

Nephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists