EPISODE · Mar 7, 2026 · 19 MIN
602-全脑功能连接预测精神病超高危状态与功能水平
from 聊聊Sci
这篇研究文章探讨了如何利用全脑功能连接来预测精神病超高风险（UHR）状态及其社会功能水平。研究人员通过对102名风险个体和105名健康对照者进行静息态功能磁共振成像（rs-fMRI）分析，发现丘脑在预测模型中扮演了核心整合枢纽的角色。结果显示，UHR个体的功能连接异常（包括过度连接与连接不足）不仅能有效区分诊断状态，还与参与者的实际生活能力密切相关。具体而言，与较差功能水平相关的神经网络在风险组中表现为过度连接，这可能反映了一种试图弥补神经缺陷的代偿机制。该研究强调了功能连接作为精神病早期阶段生物标志物的潜力，为识别功能受损的神经基础提供了重要依据。References: Ambrosen K S, Kristensen T D, Glenthøj L B, et al. Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning[J]. Schizophrenia, 2026.前往小宇宙评论区与主播互动
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602-全脑功能连接预测精神病超高危状态与功能水平
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