EPISODE · Mar 9, 2026 · 23 MIN
612-鼠脑发育过程中的补体系统空间转录组图谱
from 聊聊Sci
这份发表于2025年的研究利用 MERFISH 空间转录组技术，构建了小鼠大脑从胚胎晚期到成年阶段的补体系统空间图谱。研究发现，绝大多数补体基因在脑内具有高度的细胞与空间异质性，其表达模式随发育进程动态调整。实验证实，大脑通过维持极低的关键蛋白酶表达来严格调控补体活性，以防稳态下的免疫损伤。研究重点揭示了替代途径激活因子 Masp3 在未成熟大脑中的高表达，并证明其缺失会导致小鼠出现空间工作记忆缺陷及皮层神经元分布异常。这些成果表明，除已知的经典途径外，替代途径在大脑发育与功能成熟中也发挥着不可或缺的作用。References: Zhang Y, Watson B, Rattan A, et al. A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice[J]. Nature Communications, 2025.前往小宇宙评论区与主播互动
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612-鼠脑发育过程中的补体系统空间转录组图谱
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