619-人胎儿小脑发育的单细胞多组学图谱

这项发表于2024年《Cell Discovery》的研究，利用单细胞多组学技术深入探讨了人类胚胎小脑的发育机制。科研团队整合了转录组学、染色质可访问性以及空间转录组数据，系统地描绘了从妊娠第13周至18周期间，小脑细胞的多样化生成与空间构建过程。研究不仅识别出具有物种特异性的基因表达模式，还发现了一类新型的菱唇神经上皮细胞群。通过分析浦肯野细胞与单极刷细胞的亚型分化，该研究揭示了调控谱系发育的关键基因调控网络。这些发现极大地提升了人类对胚胎期小脑细胞起源及结构形成的认知，为理解相关神经发育障碍提供了宝贵的数据资源。References:* Yang F, Zhao Z, Zhang D, et al. Single-cell multi-omics analysis of lineage development and spatial organization in the huma...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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这项发表于2024年《Cell...

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