EPISODE · May 26, 2025 · 8 MIN
62. 抑制15-PGDH保护大脑屏障
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这篇文章讨论了酶15-PGDH在阿尔茨海默病（AD）和创伤性脑损伤（TBI）发展中的作用。研究发现，这种酶在AD、TBI以及衰老的大脑中水平升高，并且主要存在于血脑屏障附近的免疫细胞中。通过药物或基因手段抑制15-PGDH，可以保护血脑屏障的完整性。重要的是，在小鼠模型中，抑制15-PGDH改善了认知功能，同时减少了神经炎症和氧化应激。这些发现表明，针对15-PGDH可能是治疗AD和TBI的一种新方法，而且这种方法可能与现有靶向淀粉样蛋白的治疗方法不同。内容来源：https://www.pnas.org/doi/10.1073/pnas.2417224122
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62. 抑制15-PGDH保护大脑屏障
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