625-CUBIC全器官与全身单细胞三维图谱

这项研究介绍了 CUBIC 器官/全身图谱，这是一套针对小鼠主要器官及新生儿全身的三维单细胞分辨率参考数据库。研究人员开发了名为 exMOVIE 的高速光片显微镜成像系统，克服了成像分辨率与工作距离之间的权衡，实现了对数以亿计细胞的快速精确定位。通过优化组织透明化技术，该团队成功绘制了包含细胞空间坐标的数字化地图，能够对发育过程和疾病状态进行全细胞组学（Cellomics）分析。实验证明，该图谱可用于量化肾脏发育中的细胞动态，并能精确识别药物引起的肺部损伤或肿瘤转移中的免疫细胞分布。这一资源为生物医学研究提供了一个标准化的空间坐标框架，有助于从系统层面深入理解生物体的生理与病理机制。References:* Yoshida S Y, Matsumoto K, Takagi S, et al. Whole-organ and whole-body 3D atlases enable ce...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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这项研究介绍了 CUBIC 器官/全身图谱，这是一套针对小鼠主要器官及新生儿全身的三维单细胞分辨率参考数据库。研究人员开发了名为 exMOVIE...

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