625-The CUBIC Organ and Body Atlas

The CUBIC Organ/Body Atlas is a groundbreaking biological resource providing three-dimensional, single-cell resolution maps of major mouse organs and the entire neonatal body. To create this atlas, researchers optimized tissue clearing protocols and developed a high-speed imaging system called exMOVIE, which overcomes traditional trade-offs between working distance and image resolution. This technology allows for the precise detection and enumeration of hundreds of millions of individual cells while maintaining their original spatial orientation. The study demonstrates the atlas's utility by tracking cellular dynamics during kidney development and quantifying tissue changes in models of acute lung injury and cancer metastasis. By offering a standardized framework for cellomics, these sources enable a systems-level understanding of how cellular organization shifts across different physiological and pathological states. The researchers have made these comprehensive datasets and interactive web tools publicly available to support broader scientific investigation into mammalian biology.前往小宇宙评论区与主播互动