629-Architecture of Hantavirus Glycoprotein Tetramers

The paper details a scientific study on the Andes virus (ANDV), a dangerous hantavirus, and the development of high-resolution structural models of its glycoprotein assembly. Researchers utilized virus-like particles (VLPs) and cryo-electron microscopy to reveal the near-atomic architecture of the viral surface, identifying how glycoprotein tetramers organize into a lattice. These structures clarify how the virus senses acidic environments to trigger membrane fusion and how specific neutralizing antibodies, such as ADI-65534, bind to the virus. Furthermore, the study explores a self-amplifying RNA vaccine candidate that successfully elicits immune responses in mice. By defining these molecular interfaces, the research establishes a critical foundation for creating structure-based vaccines and therapeutics against hantaviruses.References: Guo L, McFadden E, Slough M M, et al. High-resolution in situ structures of hantavirus glycoprotein tetramers[J]. bioRxiv, 2025.前往小宇宙评论区与主播互动