#63 - Adipose tissue adaptations to exercise and exercise and antipsychotics with Dr David Wright

Dr Glenn McConell chats with Professor David Wright from the University of British Columbia, Canada. He has undertaken a lot of important work on the effect of exercise on muscle glucose uptake and mitochondria and then has branched out to examine the effect of exercise training on mitochondria in adipose tissue (fat). We discussed his work around that and then talked about an interesting new focus of his work around the metabolic effects of antipsychotics. He is finding that exercise can prevent the acute blood glucose raising effects of antipsychotics. A very interesting chat.0:00. Introduction and how David got into research6:10. His transition from muscle to fat research10:05. Exercise activates AMPK in muscle and fat10:57. Adipose tissue breakdown during exercise13:58. Adrenaline/epinephrine15:28. Exercise training effects on fat mitochondria21:00. Why so much fat turnover during exercise24:00. Fat use during ex in lean vs obese26:25. Adrenaline regulation of fat adaptations to ex training29:50. AMPK regulation of fat32:05. Cross talk between organs during exercise34:55. White, beige, brown adipose tissue39:00. Human vs rodents brown adipose tissue44:25. Adipokines and exercise training48:40. Ectopic fat49:40. Antipsychotics, obesity and diabetes51:15. Each dose of an antipsychotic increases blood glucose53:00. Exercise prevents these glucose effects of antipsychotics59:00. GLP-1, glucagon and antipsychotics1:03:20. Poor exercise adherence, do fasting instead?1:05:15. Ketogenic diets and antipsychotics1:08:50. Ketogenic diets and mental health1:11:03. Clinicians awareness etc.1:12:45. Sex and age differences1:15:00. Acute vs chronic effects1:15:40. Takeaway messages1:19:27. Outro (9 seconds)Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice