EPISODE · Mar 13, 2026 · 21 MIN
632-丙酮酸诱导STAT1丙酮酰化抑制抗病毒免疫
from 聊聊Sci
这项研究揭示了糖代谢产物丙酮酸在免疫调节中的一种全新非代谢功能。研究发现，在高血糖环境下，增强的糖酵解过程会导致STAT1蛋白在Lys201位点发生丙酮酰化修饰。这种新发现的蛋白质翻译后修饰会阻断STAT1与STAT2的结合，进而抑制I型干扰素（IFN-I）信号通路的激活。实验证明，通过基因手段抑制该修饰能显著提升小鼠的抗病毒免疫力。该成果不仅解释了高血糖患者为何更易受到病毒感染，还为改善糖尿病患者及干扰素治疗不敏感人群的临床策略提供了理论依据。References: Zuo Y, Wang Q, Tian W, et al. Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation[J]. Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
632-丙酮酸诱导STAT1丙酮酰化抑制抗病毒免疫
0:00
21:14
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 21 minutes long.
When was this 聊聊Sci episode published?
This episode was published on March 13, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!