EPISODE · Mar 15, 2026 · 20 MIN
643-上皮间充质转化与癌症干细胞：分化与去分化的交汇
from 聊聊Sci
这份研究报告探讨了上皮-间质转化（EMT）与细胞分化状态之间复杂且看似矛盾的联系。作者指出，虽然发育过程中的 EMT 通常被视为分化步骤，但癌症中的 EMT 则表现为增加细胞干性的去分化过程。为了统一这些观点，文章提出 EMT 会诱导暂时性的去分化，从而打破原有的分化障碍并重塑基因表达。这种机制在胚胎发育中允许组织形成，而在肿瘤中则催生了具有自我更新和耐药能力的癌症干细胞。最终，研究强调了 EMT 转录因子通过抑制特定的微小 RNA，在调节细胞可塑性中发挥着核心作用。References: Wang H, Unternaehrer J J. Epithelial‐mesenchymal transition and cancer stem cells: At the crossroads of differentiation and dedifferentiation[J]. Developmental Dynamics, 2019, 248(1): 10-20.前往小宇宙评论区与主播互动
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643-上皮间充质转化与癌症干细胞：分化与去分化的交汇
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