EPISODE · Mar 16, 2026 · 19 MIN
648-血液细胞谱系发育中可剪接外显子的功能景观
from 聊聊Sci
该研究开发了名为 FAScore 的机器学习模型，旨在从脊椎动物造血过程的数千个外显子跳跃事件中，精准筛选具有生物学功能的替代剪接（AS）。研究团队整合了人类、小鼠及其他物种在胚胎发育与细胞分化中的转录组动态数据，并结合蛋白质结构和进化保守性等19项特征，成功识别出影响造血谱系决定的关键剪接事件。实验重点验证了 TBC1D23 基因的第15号外显子。研究发现，该外显子的缺失会显著增强其与 RanBP2/RANGAP1 复合物的结合，进而提升 HDAC1 的 SUMO 化修饰水平，最终阻碍小鼠和斑马鱼的红细胞生成。此项工作不仅揭示了造血调控的新机制，还为研究其他复杂生理过程中的功能性剪接提供了通用的方法学范式。References: Hu X, Wang J, Chen L, et al. The functional landscape of alternative splicing in hematopoietic lineage commitment[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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648-血液细胞谱系发育中可剪接外显子的功能景观
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