EPISODE · Mar 16, 2026 · 14 MIN
650-血管STING激活促进小细胞肺癌NK细胞免疫治疗
from 聊聊Sci
这项研究探讨了小细胞肺癌（SCLC）通过抑制MHC-I类分子表达来逃避免疫监管的机制。虽然这类神经内分泌肿瘤理论上对自然杀伤（NK）细胞高度敏感，但临床观察发现免疫细胞被排除在肿瘤区域之外。通过创新的DynaMITE-seq技术和三维微生理模型，研究人员确认肿瘤血管系统是阻碍免疫细胞进入的关键屏障。实验证明，激活血管中的STING信号通路能上调粘附分子的表达，从而诱导NK细胞的招募与渗透。这种策略不仅能增强内源性免疫反应，还能显著提升DLL3靶向的CAR-NK细胞疗法在实体瘤中的杀伤效力。这项工作为将“冷肿瘤”转变为“热肿瘤”并优化细胞免疫治疗提供了新的临床思路。References: Campisi M, Osaki T, Dryg I, et al. Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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650-血管STING激活促进小细胞肺癌NK细胞免疫治疗
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