653-多巴胺通路编码社交驱动的探索决策

这项发表在《Neuron》上的研究揭示了社交陪伴如何通过大脑多巴胺系统增强小鼠的探索行为。研究发现，腹侧被盖区（VTA）的多巴胺神经元是核心枢纽，其爆发式放电编码对风险的警觉，而稳态放电则驱动探索动力。社交互动能使这些神经元的活动模式发生转变，通过增加稳态放电来提升动机，并降低其对风险深度的敏感性。这一过程涉及两条相互竞争的回路：直接路径（VTA-BLA）介导回避行为，而经由内侧前额叶皮层（mPFC）的间接路径则促进探索。这两条路径最终汇聚在**基底侧杏仁核（BLA）**的特定神经元上，通过整合不同的多巴胺信号来协调最终的探索决策。该成果为理解社交行为如何正向调节哺乳动物的冒险动机提供了精细的神经环路机制。References:* Zheng C, Liu X, Wei A, et al. Converging dopamine pathways onto basolateral am...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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