659-全能内分泌亚型人类多能干细胞衍生胰岛的重建 episode artwork

EPISODE · Mar 18, 2026 · 19 MIN

659-全能内分泌亚型人类多能干细胞衍生胰岛的重建

from 聊聊Sci

这份研究报告介绍了一种利用人类多能干细胞重建胰岛的新技术。科研人员成功培育出包含全部五种内分泌细胞亚型的类胰岛组织,并实现了对其细胞比例的精准调控。通过在患有糖尿病的小鼠身上进行移植实验,这些重建胰岛展现了卓越的双向血糖调节能力。该项成果最显著的突破在于其能有效防止低血糖的发生,弥补了以往干细胞疗法在安全性上的短板。这为糖尿病患者提供了一种更具生理功能的细胞替代疗法,有助于恢复人体自然的代谢平衡。References: Meng G, Gu J, Liew S Y, et al. Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo[J]. Cell Stem Cell, 2025, 32(9): 1438-1456. e7.前往小宇宙评论区与主播互动

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659-全能内分泌亚型人类多能干细胞衍生胰岛的重建

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