EPISODE · Mar 19, 2026 · 14 MIN
662-SC291低免疫CD19 CAR T细胞临床免疫逃避研究
from 聊聊Sci
这份报告研究了名为 SC291 的新型通用型 CD19 CAR T 细胞在癌症和自身免疫病患者中的临床表现。该细胞经过低免疫（HIP）基因编辑，通过敲除 HLA 并过表达 CD47 来逃避人体的免疫排斥。临床数据显示，尽管患者会对未完全编辑的细胞产生攻击，但完全编辑的 HIP CAR T 细胞在所有患者中均能成功避开 T 细胞、NK 细胞及抗体的检测与杀伤。此外，研究发现患者体内若不产生针对 HLA 的特定抗体，可作为深层组织 B 细胞耗竭的有效监测指标。这些发现证实了 HIP 技术在开发无需严格免疫抑制的通用型细胞疗法方面的可靠潜力。References: Hu X, Beauchesne P, Wang C, et al. Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease[J]. Cell Stem Cell, 2025, 32(9): 1356-1368. e4.前往小宇宙评论区与主播互动
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662-SC291低免疫CD19 CAR T细胞临床免疫逃避研究
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