664-GENEVA：解析肿瘤嵌合性与药物反应的多元平台

这项名为 GENEVA 的研究推出了一种具有单细胞分辨率的可扩展平台，旨在通过整合多种患者来源和癌症细胞系，模拟肿瘤的遗传多样性。该系统克服了传统异种移植模型难以规模化的限制，能够在单一实验中同时观察三维培养和活体模型对药物干预的反应。研究人员利用该平台深入分析了 KRAS-G12C 抑制剂的疗效，发现线粒体激活是诱导细胞死亡的关键机制。同时，研究通过对比体内外数据，识别出上皮-间质转化（EMT）是导致药物耐受的主要原因。最终，这项技术成功预测并验证了多种联合用药方案，为弥补临床前模型与患者实际疗效之间的差距提供了强有力的工具。References: Yu J X, Suh J M, Popova K D, et al. The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations[J]. Nature Cancer, 2026: 1-16.前往小宇宙评论区与主播互动

Episode metadata supplied by the publisher feed · Published Mar 19, 2026

Embed this episode

Attribution link and audio player

Ready to play

664-GENEVA：解析肿瘤嵌合性与药物反应的多元平台

0:00 16:30

1×

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Share this episode

Similar Episodes

No similar episodes found.

Similar Podcasts

Forfeiture Book Review: Ecocide and Sci-Fi JP et al. A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra Deep Dream State Neural Nets And Pretty Patterns Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.

Frequently Asked Questions

How long is this episode of 聊聊Sci?

This episode is 16 minutes long.

When was this 聊聊Sci episode published?

This episode was published on March 19, 2026.

Can I download this 聊聊Sci episode?

Yes. Use the download control on the episode player to save the publisher-provided media file.

URL copied to clipboard!