EPISODE · Mar 19, 2026 · 24 MIN
665-CRTAM：免疫检查点阻断治疗中解耦疗效与毒性的新靶点
from 聊聊Sci
这项研究揭示了 CRTAM 分子在免疫检查点阻断治疗中作为特定免疫相关副作用（irAEs）控制点的关键作用。研究团队通过分析转录组和临床数据发现，抑制 CRTAM 能够有效减轻如肠炎和肺炎等免疫毒性症状，且不会削弱免疫治疗对肿瘤的打击力度。实验表明，CRTAM+ T细胞会利用 CADM1 受体优先浸润正常组织而非肿瘤，并诱导导致组织炎症的3型免疫反应。通过遗传敲除或药物阻断 CRTAM-CADM1 轴，科研人员成功实现了免疫治疗中“减毒不减效”的平衡。此外，监测血液中的 CRTAM 相关免疫指标，也为临床预测和评估免疫治疗副反应提供了新的生物标志物。References: Ma S C, Rong Z X, Xu Z P, et al. CRTAM inhibition mitigates toxicity of immune checkpoint inhibitors without antitumor efficacy trade-off[J]. Nature Cancer, 2026: 1-17.前往小宇宙评论区与主播互动
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665-CRTAM：免疫检查点阻断治疗中解耦疗效与毒性的新靶点
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