EPISODE · Mar 20, 2026 · 16 MIN
666-基于METTL3的上皮转录组编辑筛选与癌症功能性m6A位点鉴定
from 聊聊Sci
这份研究报告介绍了一种新型表观转錄组编辑筛选平台，旨在系统性识别癌症中具有功能意义的 m6A RNA 修饰位点。通过利用 dCasRx-METTL3 技术，研究人员在肺癌和前列腺癌模型中精准定位了 222 个影响细胞增殖的位点。研究重点揭示了 CHD9 基因上的 m6A 修饰在前列腺癌中发挥的关键抑癌作用。该位点的修饰通过 YTHDF1/3 阅读器增强了 CHD9 的蛋白翻译，进而维持 MYBBP1A 蛋白在核质中的定位，并激活 CDKN1A (p21) 信号通路。这项成果不仅为系统性探索 RNA 修饰提供了可扩展的研究框架，还为癌症治疗发现了新的分子靶点。References: Xu X, Wang Y, Zhu H, et al. METTL3-based epitranscriptomic editing screening identifies functional m6A sites in cancers[J]. Nature Cancer, 2026: 1-15.前往小宇宙评论区与主播互动
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666-基于METTL3的上皮转录组编辑筛选与癌症功能性m6A位点鉴定
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