#67 - Limitations to VO2 max with Professor Jose Calbet

Dr Glenn McConell chats with Professor José Calbet from the University of Las Palmas de Gran, Canary Islands, Spain. José has a very strong research record and is a global leader in his field. He has done amazing invasive exercise studies in humans to determine the limiting factor(s) to VO2 max. We talked about what is VO2 max, the factors determining VO2 max, the limits to VO2 max, the effects of VO2 max on exercise performance, pseudoanemia, VO2 max in females, VO2 max in masters athletes etc. In general he is finding the oxygen delivery is the main limiting factor to VO2 max. A very interesting, long chat. Twitter: @GRHEFS_ULPGC 0:00. Introduction and how José got into exercise research4:55. Links with Bengt Saltin and University of Copenhagen9:12. What is VO2 max?10:59. Cardiac output and blood pressure14:15. Blood pressure can drop near VO2 max15:30. Maximum heart rate/ stroke volume17:50. Submaximal exercise in trained vs untrained19:06. Oxygen extraction during exercise24:40. Main limiting factor to VO2 max27:41. Capillaries and muscle mitochondria30:31. Hemoglobin concentration and oxygen delivery32:40. Athletes limited by oxygen delivery/temptation of EPO34:35. VO2 max in women: lower hemoglobin38:19. Pseudoanemia in endurance athletes45:42. How does high Hb mass improve submax performance?49:42. Role of genetics and ex training in VO2 max56:18. Responders and non responded to exercise training?58:50. Blood flow restraint to maintain blood pressure1:05:35. Masters athletes vs young untrained1:12:43. Ex training can slow the decease in max HR with age1:17:51. Does life long exercise slow the reduction in VO2 max?1:21:19. Loss of mitochondria with age vs inactivity1:24:40. David Costill. 70 ml/kg/min VO2 max enough?1:31:50. Sex differences in metabolism during exercise1:36:00. How does creatine supplementation reduce VO2 max?1:37:29. How know how close to VO2 max potential you are at?1:42:38. Hyperthermia, ventilation and blood flow1:45:41. Can increase VO2 max by giving vasodilators?1:48:05. Hypoxia doesn’t increase VO2 max1:49:44. Takeaway messages1:50:40. VO2 max and life expectancy1:53:00. José feels lucky/Bengt Saltin/University of Copenhagen1:54:32. Outro (9 seconds)Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice