EPISODE · Mar 21, 2026 · 20 MIN
671-中性粒细胞与乳腺癌细胞的物理互作及成瘤机制
from 聊聊Sci
这项研究利用单细胞RNA测序与物理相互作用细胞测序技术，系统分析了乳腺癌发展过程中中性粒细胞的异质性及其功能。研究发现，这些免疫细胞在癌症晚期会与肿瘤细胞发生直接物理接触，并由肿瘤相关巨噬细胞招募至肿瘤微环境中。这种物理相互作用不仅激活了促进肿瘤增殖和血管生成的特定基因程序，还形成了一个支持癌症侵袭的信号微环境。此外，研究确定了一种与患者生存率降低显著相关的促癌分子特征，为乳腺癌的临床治疗提供了新的生物标志物和潜在靶点。References: Camargo S, Moskowitz O, Giladi A, et al. Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness[J]. Nature Cancer, 2025, 6(3): 540-558.前往小宇宙评论区与主播互动
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671-中性粒细胞与乳腺癌细胞的物理互作及成瘤机制
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