EPISODE · Mar 21, 2026 · 23 MIN
673-骨骼肌内皮功能障碍驱动癌症恶病质进展
from 聊聊Sci
这项研究指出，骨骼肌内皮功能障碍是导致癌症恶病质（肌肉萎缩）的核心驱动因素。研究人员通过多种肿瘤模型发现，肌肉血管密度的降低实际上发生在肌肉萎缩之前，这一现象在癌症患者身上也得到了验证。研究揭示了肿瘤释放的激活素 A（Activin A）会抑制肌肉血管内皮中的 PGC1α 表达，进而引发血管渗漏和功能衰竭。实验证明，修复内皮细胞中的 PGC1α 活性能够有效维持血管密度并减缓肌肉流失。因此，针对改善血管内皮功能而非仅仅针对肌肉本身，可能成为治疗癌症恶病质的新策略。References: Kim Y M, Sanborn M A, Vijeth S, et al. Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia[J]. Nature Cancer, 2025, 6(8): 1350-1369.前往小宇宙评论区与主播互动
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673-骨骼肌内皮功能障碍驱动癌症恶病质进展
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