EPISODE · Mar 21, 2026 · 16 MIN
675-癌细胞线粒体转移诱导成纤维细胞重编程
from 聊聊Sci
这项研究揭示了癌细胞通过细长的隧道纳米管（TNTs）向成纤维细胞传递线粒体的生物学机制。这种线粒体转移会诱导成纤维细胞发生代谢改变，并使其分化为癌相关成纤维细胞（CAFs）。研究指出，该过程关键取决于线粒体运输蛋白 MIRO2，下调该蛋白可有效抑制线粒体交换及肿瘤生长。分化后的成纤维细胞会释放促进肿瘤发展的分泌组和基质组，从而在临床前模型中加速癌症进展。临床观察进一步证实，MIRO2 在皮肤癌边缘高度表达，显示了该机制在人类恶性肿瘤中的相关性。这些发现为通过干扰线粒体转移来阻断肿瘤微环境的恶化提供了新的治疗思路。References: Cangkrama M, Liu H, Wu X, et al. MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation[J]. Nature Cancer, 2025, 6(10): 1714-1733.前往小宇宙评论区与主播互动
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675-癌细胞线粒体转移诱导成纤维细胞重编程
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