EPISODE · Mar 25, 2026 · 21 MIN
692-小鼠多能干细胞体外重建睾丸生态位与性别决定
from 聊聊Sci
这项研究成功利用小鼠多能干细胞在体外重建了睾丸性状决定过程及其实质微环境。科研人员通过精确调控信号通路，诱导出能自发形成生精小管结构的睾丸体细胞样细胞（TesLCs），打破了以往必须依赖胚胎组织的局限。实验证明，这些人工构建的睾丸类器官能够支持生殖细胞发育为具有功能的精原干细胞。将这些干细胞移植到小鼠体内后，成功产生了可受精的成熟精子并孕育出健康的后代。此外，研究还揭示了性染色体在性别分化中的不对称性，发现XY型细胞在特定条件下也能转化为卵巢辅助细胞。该成果为理解哺乳动物性别发育机制及体外配子发生提供了关键的实验平台。References: Yoshino T, Sasada H, Sato T, et al. Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells[J]. Science, 2026, 391(6788): eaea0296.前往小宇宙评论区与主播互动
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692-小鼠多能干细胞体外重建睾丸生态位与性别决定
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