EPISODE · Mar 25, 2026 · 20 MIN
694-哺乳动物昼夜节律切换的细胞基础
from 聊聊Sci
这项发表在《Science》杂志的研究揭示了哺乳动物在昼行性与夜行性之间切换的细胞生物学机制。研究发现，虽然不同哺乳动物拥有相似的核心生物钟，但其外周细胞对温度和渗透压等环境信号的反应方向截然不同。mTOR和WNK信号通路在其中发挥了关键作用，昼行性物种通过进化增强了细胞对热力学扰动的鲁棒性，从而实现了昼夜节律的倒置。实验证明，抑制小鼠等夜行性动物的mTOR活性，足以使其细胞和行为节律向昼行性模式转变。这一发现不仅解释了昼行性在哺乳动物中多次独立进化的原因，还强调了细胞内在机制在决定物种生态位中的核心地位。References: Beale A D, Christmas M J, Rzechorzek N M, et al. A cellular basis for the mammalian nocturnal-diurnal switch[J]. Science, 2026, 391(6788): eady2822.前往小宇宙评论区与主播互动
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