EPISODE · Mar 25, 2026 · 20 MIN
696-肿瘤-免疫-神经回路与癌症恶病质研究
from 聊聊Sci
这项研究揭示了癌症恶病质（身体虚弱和消瘦）背后的一种关键肿瘤-免疫-神经环路机制。研究发现，肿瘤分泌的CSF1会诱导巨噬细胞产生GDF15细胞因子，该因子随后激活中枢神经系统中的GFRAL-RET轴。这种激活通过交感神经系统释放去甲肾上腺素，进一步增强肿瘤细胞中ZIP4和CSF1的表达，从而形成一个加剧全身性消耗的反馈循环。实验证明，缺失GDF15或利用抗体和抑制剂阻断该通路，能有效缓解实验模型中的食欲不振、肌肉萎缩和脂肪流失。这一发现不仅阐明了肿瘤、免疫细胞与神经系统之间的复杂互动，还为开发治疗癌症恶病质的新型靶向疗法提供了理论依据。References: Shi X, Arreola A X, Zhou Z, et al. Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia[J]. Cancer cell, 2026.前往小宇宙评论区与主播互动
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696-肿瘤-免疫-神经回路与癌症恶病质研究
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