EPISODE · Mar 26, 2026 · 28 MIN
697-小鼠全脑昼夜神经活动单细胞图谱
from 聊聊Sci
这项发表在《Science》上的研究通过对144个小鼠大脑进行组织透明化与c-Fos免疫染色，构建了首个全脑单细胞水平的昼夜节律神经活动图谱。研究发现，在恒定黑暗环境下，大脑中约79%的区域表现出显著的昼夜振荡，且不同功能区（如视觉、听觉、记忆及睡眠调节区）在活跃相和非活跃相呈现出不同的峰值活动模式。通过体素级分析，科学家揭示了单一脑区内部复杂的时空协调性，并能仅凭脑内c-Fos的全局分布模式精准预测生物钟时间。最后，研究团队建立了一个开放获取数据库，为神经科学、药物研发及疾病研究提供了一个整合分子、解剖与时间的全球化视角。References: Yamashita K, Kinoshita F L, Yoshida S Y, et al. A whole-brain single-cell atlas of circadian neural activity in mice[J]. Science, 2025: eaea3381.前往小宇宙评论区与主播互动
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697-小鼠全脑昼夜神经活动单细胞图谱
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