699-哺乳动物衰老全组织单细胞染色质图谱

这项研究通过构建全组织单细胞染色质开放性图谱，系统地揭示了哺乳动物在衰老过程中的细胞动力学与表观遗传重塑。研究人员利用先进的 EasySci-ATAC 技术，分析了来自不同年龄和性别小鼠 21 种组织的超过 1000 万个细胞核。实验识别出逾 130 万个顺式调节元件，并记录了数百种细胞类型随时间推移发生的数量增减与功能转变。结果显示，衰老引起了广泛的染色质结构重组，且这种变化在不同性别间表现出显著的二元差异。该研究不仅为理解衰老的分子逻辑提供了核心资源，还为开发针对老龄化相关疾病的精准干预手段奠定了基础。References: Lu Z, Zhang Z, Xu Z, et al. Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging[J]. Science, 2026, 391(6788): eadw6273.前往小宇宙评论区与主播互动

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699-哺乳动物衰老全组织单细胞染色质图谱

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