EPISODE · Mar 26, 2026 · 20 MIN
700-细胞综合应激反应的终止机制
from 聊聊Sci
这项发表在《Science》杂志上的研究，揭示了细胞如何通过终止集成应激反应（ISR）来恢复蛋白质合成。科学家发现，磷酸酶调节亚基 R15B 不仅能结合游离的底物，还能识别被磷酸化的 eIF2 与其抑制对象 eIF2B 形成的庞大复合体。通过冷冻电子显微镜技术，研究证明 R15B 能够通过脱磷酸作用将 eIF2B 从抑制状态中解救出来，从而重新激活翻译过程。此外，该研究还意外发现了 eIF2Bγ 亚基上存在一个 GTP 结合位点，且该区域的基因突变与罕见的脑白质变性病（VWMD）密切相关。这一成果不仅解析了应激信号终止的分子机制，也为相关神经退行性疾病提供了新的病理视角。References: De Miguel C, Thorkelsson S R, Fatalska A, et al. Termination of the integrated stress response[J]. Science, 2025: eadw5137.前往小宇宙评论区与主播互动
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