EPISODE · Mar 27, 2026 · 27 MIN
704-STING-NF-κB信号通路构建流感病毒跨物种传播屏障
from 聊聊Sci
这篇研究文章阐明了人体内的STING蛋白如何通过NF-κB信号通路构建起一道阻断禽流感病毒（IAV）跨物种传播的免疫屏障。研究发现，STING蛋白的Gly90位点对于激活该抗病毒通路至关重要，并能诱导产生关键的限制因子GADD34来抑制病毒复制。为了克服这一宿主防御，人类流感病毒通过其M1蛋白的Ile115突变进化出了逃逸机制，使其能有效对抗人类而非鸟类的STING防御。这项发现不仅揭示了流感病毒实现跨物种溢出的分子机制，还为预测大流行风险和开发新型广谱抗病毒疗法提供了重要靶点。References: Ye R, Wang S, Hu Y, et al. STING–NF-κB signaling builds an influenza spillover barrier[J]. Science, 2026, 391(6788): eads4405.前往小宇宙评论区与主播互动
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704-STING-NF-κB信号通路构建流感病毒跨物种传播屏障
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