EPISODE · Mar 28, 2026 · 22 MIN
709-抑制细胞周期蛋白可增强人体疟疾抗性
from 聊聊Sci
这篇文章探讨了rs112233623-T基因变异如何通过降低细胞周期蛋白cyclin D3的表达来增强人体对疟疾的抵抗力。研究发现，这种变异在曾受疟疾困扰的萨丁岛人群中频率极高，暗示其在进化过程中因能阻止寄生虫在红细胞内生长而受到自然选择。该变异通过改变增强子序列，导致红细胞数量减少、体积增大且血红蛋白浓度升高，从而限制了恶性疟原虫的繁殖。虽然由于该地区已根除疟疾而难以进行流行病学验证，但实验结果明确支持了其保护作用。这一发现不仅揭示了一种新的遗传保护机制，还为利用细胞周期蛋白抑制剂开发新型疟疾治疗方案提供了可能。References: https://www.nature.com/articles/d41586-026-00289-2前往小宇宙评论区与主播互动
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709-抑制细胞周期蛋白可增强人体疟疾抗性
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