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71. What are the World's Biggest Problems? episode artwork

Jan 21, 2026 19 min

71. What are the World's Biggest Problems?

from The ManuScript with Manu Edakkara Hosted by the.manuscript

What are the world’s biggest problems—and how should we decide? In this episode, I examine two influential but very different frameworks for global priorities: the United Nations, which focuses on present human suffering and politically actionable goals, and 80,000 Hours, which prioritizes catastrophic and existential risks that could permanently alter humanity’s future. Rather than listing issues, this episode asks a deeper question: Should we prioritize problems that harm millions today, or those that could end civilization tomorrow? Topics include: Poverty, health, climate change, and conflict Nuclear war, pandemics, and AI risk Why prevention is undervalued The moral tension between certainty and catastrophe What responsibility means in a world with unprecedented power This is a calm, analytical conversation about risk, ethics, and the long-term future—without activism, hype, or easy answers. Episode on self-actualization https://open.spotify.com/episode/2JjRwLjNm8w6U7krHLkDb3 Numbers behind economic inequality: https://open.spotify.com/episode/7r1n63M2bCJ0ydVO6rvP3v https://sdgs.un.org/goals https://80000hours.org/problem-profiles/

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