EPISODE · Mar 28, 2026 · 15 MIN
710-利用蛋白质冠实现脂质纳米颗粒的胰腺靶向
from 聊聊Sci
这篇文章概述了脂质纳米颗粒（LNP）在药物递送领域的重大进展，重点介绍了一项实现胰腺精准靶向的创新研究。研究人员利用腹腔注射和特定的脂质改性，使微小的纳米颗粒在体内吸附蛋白质，形成直径约300纳米的蛋白质冠，从而利用胰腺被膜较薄的解剖特性实现器官定位。通过在脂质中添加精氨酸-组氨酸二肽，LNP能够吸引特定的脂质结合蛋白，并利用VLDL受体介导细胞摄取，从而特异性地将治疗性mRNA递送至间充质基质细胞（MSC）。这种基于机制驱动的被动与主动靶向结合策略，成功克服了LNP易被肝脏捕获的传统局限。实验证明，该方法在治疗胰腺癌等难治性疾病方面展现出巨大潜力，为设计具有器官和细胞特异性的递送系统提供了新范式。References: https://www.nature.com/articles/d41586-026-00294-5前往小宇宙评论区与主播互动
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710-利用蛋白质冠实现脂质纳米颗粒的胰腺靶向
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