EPISODE · Mar 29, 2026 · 18 MIN
711-基因图谱解码：精准逆转T细胞竭竭与免疫记忆修复
from 聊聊Sci
这项研究通过构建一个多组学计算图谱，成功揭示了决定CD8+ T细胞走向功能衰竭或持久记忆的关键基因开关。研究人员利用Taiji算法锁定了ZSCAN20和JDP2等转录因子，发现它们是诱导细胞进入末端衰竭状态的核心驱动者。通过基因编辑手段剔除这些特定因子，能够显著恢复T细胞杀伤肿瘤的能力，且不会破坏维持长期免疫保护的组织驻留记忆细胞。这一发现突破了以往两者在基因表达上高度相似而难以区分的难题，实现了对免疫细胞状态的精确重编程。该科研框架不仅提升了现有的免疫疗法效力，还为未来设计更耐用、更智能的人造细胞药物提供了通用型蓝图。References: Chung H K, Liu C. Immune cells could be protected from'exhaustion'by flipping genetic switches[J]. 2026.前往小宇宙评论区与主播互动
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711-基因图谱解码：精准逆转T细胞竭竭与免疫记忆修复
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