EPISODE · Mar 30, 2026 · 17 MIN
718-SelO催化的NAD+水解与线粒体稳态维持
from 聊聊Sci
这份研究揭示了线粒体中的SelO酶（在细菌中称为ydiU）通过水解NAD+生成NMN和AMP的生化机制。该反应受线粒体基质pH值升高的驱动，能够响应呼吸链的过度激活并发挥保护作用。研究发现，SelO通过其高度保守的硒半胱氨酸残基发挥催化活性，并能直接结合脂肪酸β-氧化（FAO）多酶复合物。在功能上，SelO介导的NAD+降解会抑制脂质代谢，从而防止线粒体因代谢过载而受损。实验表明，缺失SelO会导致线粒体稳态失衡、形态破碎以及肝脏损伤，证明了其在维持细胞能量平衡中的关键作用。该发现为理解细胞如何空间精确调控NAD+水平及应对代谢应激提供了重要理论依据。References: Jia X, Zhang T, Yang C, et al. NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis[J]. Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
718-SelO催化的NAD+水解与线粒体稳态维持
0:00
17:29
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 17 minutes long.
When was this 聊聊Sci episode published?
This episode was published on March 30, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!