718-SelO催化的NAD+水解与线粒体稳态维持

这份研究揭示了线粒体中的SelO酶（在细菌中称为ydiU）通过水解NAD+生成NMN和AMP的生化机制。该反应受线粒体基质pH值升高的驱动，能够响应呼吸链的过度激活并发挥保护作用。研究发现，SelO通过其高度保守的硒半胱氨酸残基发挥催化活性，并能直接结合脂肪酸β-氧化（FAO）多酶复合物。在功能上，SelO介导的NAD+降解会抑制脂质代谢，从而防止线粒体因代谢过载而受损。实验表明，缺失SelO会导致线粒体稳态失衡、形态破碎以及肝脏损伤，证明了其在维持细胞能量平衡中的关键作用。该发现为理解细胞如何空间精确调控NAD+水平及应对代谢应激提供了重要理论依据。References:* Jia X, Zhang T, Yang C, et al. NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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