EPISODE · Mar 30, 2026 · 20 MIN
719-代谢物调控的血管收缩开关：OXGR1治疗玫瑰痤疮机制研究
from 聊聊Sci
这份研究揭示了α-酮戊二酸（α-KG）在缓解玫瑰痤疮红斑中的关键作用及其分子机制。研究发现，这种代谢物能特异性激活血管平滑肌细胞中的OXGR1受体，通过Gq-MYL9信号轴诱导血管收缩，从而抑制病理性血管扩张。通过冷冻电镜技术，科学家成功解析了受体独特的双酸结合口袋结构，阐明了配体识别的结构基础。基于此结构，研究者筛选并开发出一种高选择性激动剂A-1，其药效显著强于天然代谢物。实验证明，A-1在改善皮肤红斑和预防复发方面具有卓越的疗效与安全性，为血管性皮肤病提供了精准治疗的新方向。References: Xiao W, Zhu Y, Tang X, et al. Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema[J]. Cell, 2026.前往小宇宙评论区与主播互动
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719-代谢物调控的血管收缩开关：OXGR1治疗玫瑰痤疮机制研究
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