EPISODE · Mar 31, 2026 · 19 MIN
723-酮体BHB增强CAR-T细胞代谢与抗肿瘤效能
from 聊聊Sci
这项研究揭示了生酮饮食产生的代谢物β-羟基丁酸 (BHB) 如何显著增强CAR-T细胞治疗癌症的效果。通过在多种临床前动物模型中进行实验，研究者发现BHB能通过强化三羧酸循环来优化T细胞的能量代谢，进而提升其增殖能力和对肿瘤的杀伤力。此外，人体志愿者的数据也证实，补充BHB可提高外周T细胞的线粒体功能。该研究表明，这种饮食或代谢干预策略为改善癌症免疫治疗提供了一种简单且极具潜力的临床途径。References: Liu S, Guruprasad P, Ramasubramanian R, et al. β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动
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723-酮体BHB增强CAR-T细胞代谢与抗肿瘤效能
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