EPISODE · Apr 1, 2026 · 23 MIN
729-衰老小鼠大脑细胞类型特异性转座子脱甲基与3D基因组重塑
from 聊聊Sci
这项研究通过构建小鼠大脑衰老的多组学单细胞图谱，深入探讨了大脑随年龄增长产生的表观遗传变化。研究利用单细胞测序技术分析了不同脑区的DNA甲基化和染色体构象，发现转座子（TE）的去甲基化是区分细胞类型和年龄的关键特征。数据表明，衰老会导致拓扑相关结构域（TAD）边界增强以及特定结合因子的开放性增加，反映出基因组三维结构的重塑。通过整合空间转录组学，研究揭示了同一细胞类型在不同脑区衰老过程中的区域异质性。此外，科学家开发出深度学习模型，能够利用多模态特征准确预测与衰老相关的基因表达变化。该成果为理解神经退行性疾病的分子机制和未来开发靶向疗法提供了重要的资源框架。References: Zeng Q, Wang W, Tian W, et al. Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain[J]. Cell, 2026.前往小宇宙评论区与主播互动
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729-衰老小鼠大脑细胞类型特异性转座子脱甲基与3D基因组重塑
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