EPISODE · Apr 2, 2026 · 23 MIN
731-SLC25A35调控线粒体PEP转运与甘油酯合成
from 聊聊Sci
这项研究揭示了SLC25A35作为一种关键的线粒体转运蛋白，负责将线粒体内生成的磷酸烯醇式丙酮酸（PEP）输出到细胞质中。实验表明，该转运过程由线粒体膜电位驱动，是脂肪细胞进行甘油异生和脂肪合成的重要环节。通过结构模拟与脂质体重建试验，研究确认了其底物特异性以及在连接线粒体能量代谢与脂质生产中的核心作用。此外，抑制肝脏中的SLC25A35能够显著减少脂肪肝并改善血糖稳态，为治疗糖尿病和肥胖相关代谢疾病提供了潜在的新靶点。该发现填补了线粒体PEP外运机制的长期空白，阐明了其在生物能学中的关键地位。References: Yamamuro T, Katoh D, Silva G M, et al. Mitochondrial control of glycerolipid synthesis by a PEP shuttle[J]. Cell, 2026.前往小宇宙评论区与主播互动
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731-SLC25A35调控线粒体PEP转运与甘油酯合成
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