EPISODE · Apr 2, 2026 · 20 MIN
733-脂质代谢重编程成纤维细胞增强化疗免疫抗癌反应
from 聊聊Sci
这项研究揭示了在膀胱癌治疗过程中，化疗会诱导产生一种特殊的PTGER3⁺成纤维细胞（lipoCAFs）。这种细胞通过脂质氧化重编程产生信号分子11-HETE，进而通过抑制PTEN蛋白的活性来增强CD8⁺ T细胞的抗癌功能。与以往发现的促癌细胞不同，这种新型亚群具有限制肿瘤生长的作用，且其存在与患者的良好预后显著相关。这一发现为克服以往成纤维细胞靶向疗法的失败提供了新视角，暗示增强该特定细胞群体或其代谢路径可能成为提升化疗疗效的创新策略。References: Mahadevan K K, Kalluri R. Tumor-restraining fibroblasts emerge after chemotherapy specifically in responders[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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733-脂质代谢重编程成纤维细胞增强化疗免疫抗癌反应
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