737-肠道内感失调驱动大脑衰老

这项研究揭示了肠道微生物群通过肠—脑轴影响衰老相关认知障碍的具体机制。研究发现，随着年龄增长，肠道内如金氏副拟杆菌（P. goldsteinii）等特定细菌会大量增加，并分泌中链脂肪酸（MCFAs）。这些代谢产物激活了骨髓细胞中的GPR84受体，进而引发外周炎症并抑制迷走神经向大脑传递信号。这种内感官功能障碍导致海马体神经元激活受损，最终引发记忆力衰退。通过噬菌体干预、GPR84抑制剂或激活迷走神经（如使用辣椒素），研究成功恢复了老年小鼠的认知能力。这些发现为开发内感官模拟药物以对抗大脑衰老提供了全新的治疗思路。References:* Cox T O, Devason A S, de Araujo A, et al. Intestinal interoceptive dysfunction drives age-associated cognitive decline[J]. Nat...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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737-肠道内感失调驱动大脑衰老

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This episode was published on April 3, 2026.

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这项研究揭示了肠道微生物群通过肠—脑轴影响衰老相关认知障碍的具体机制。研究发现，随着年龄增长，肠道内如金氏副拟杆菌（P....

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