#74- Are beta2-agonists just asthma treatments or also performance enhancers? With Dr Morten Hostrup

Dr Glenn McConell chats with Associate Professor from the University of Copenhagen, Denmark. He is an expert on the effect of beta2-agonist asthma bronchodilator medications (like Ventolin) on muscle and exercise performance. We talked about what is asthma/exercise induced bronchoconstriction, can you train your lungs?, the increased prevalence of asthma in endurance athletes, can asthma limit aerobic capacity, what are beta2-agonists?, acute and chronic effects of beta2-agonists on muscle mass, sprinting, strength and endurance, side effects of beta2-agonists and negative effects of beta2 agonists on endurance exercise. Beta2-agonists should only be used for asthma treatment. A very interesting chat. Twitter: @morten_hostrup.0:00. Introduction2:12. Morten’s very good excuse for postponing coming on5:15. What is asthma?6:50. Lungs in endurance athletes vs general population1:11:15. Increased asthma in endurance athletes13:58. Why more asthma in endurance athletes?17:20. Asthmatic athletes can be very successful19:50. VO2 max etc not effected by asthma24:18. Beta2-agonists can have negative effects on VO2 max26:30. Sympathetic/parasympathetic nervous systems29:06. What are Beta2-agonists and what do they do?31:30. Inhaled medications can get into the blood32:40. Different beta2-agonists35:23. Legitimate and illegitimate use of beta2-agonists40:30. Up to 90% of some cohorts take beta2-agonists42:30. Legal limits of beta2-agonists use43:40. Acute effects on muscle mass/ sprinting49:02. Mechanisms of effect on muscle53:13. How limit misuse?56:39. Chronic effects on muscle1:02:50. Hypertrophy from chronic beta2-agonists1:06:15. Prevalence of use in body builders1:07:40. Combined use of drugs in body builders1:10:00. Effect of combining with corticosteroids1:16:30. Normal doses have small effects on muscle1:17:10. Side effects1:21:00. Mechanisms of chronic beta2-agonists on muscle1:23:30. Muscle mass and insulin sensitivity1:27:22. Potency vs anabolic steroids etc1:29:35. Competition with beta blockers1:31:55. Cycling on and off beta2-agonists?1:32:35. Effects during exercise1:37:04. Anti-diabetic effects?1:38:15. Maintains muscle mass during weight loss1:39:30. Alzheimer’s and Parkinson’s disease1:40:55. Sex differences1:42:40. Age effects1:43:40. Does exercise training affect beta2 receptors?1:44:45. Negative effects on endurance exercise1:47:02. Increase muscle mass but not so much strength1:50:20. Controversies in the field1:52:30. Some claim beta2 agonists have no systemic effects1:58:00. Takeaway messages1:59:28. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice